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In the latest research, we described the identification along with the characterization of a whole new atypical opioid receptor with unique detrimental regulatory Attributes toward opioid peptides.1 Our benefits confirmed that ACKR3/CXCR7, hitherto known as an atypical scavenger receptor for chemokines CXCL12 and CXCL11, is additionally a broad-spe